Direct borylation of C-H bonds is a privileged strategy to access versatile building blocks and valuable derivatives of complex molecules (late-stage functionalization, metabolite synthesis). This perspective aims to provide an overview and classification of the catalytic systems developed in this fast-growing area of research. Unexpected selectivity differences between two established directed-borylation systems have been discovered using high-throughput experimentation highlighting the importance of classical control experiments in catalysis research.
Keywords: Borylation; C-H activation; Imine ligand; Iridium.
Copyright 2024 Janis M. Zakis, Simone L. Kuhn, Joanna Wencel-Delord, Tomas Smejkal. License: This work is licensed under a Creative Commons Attribution 4.0 International License.