Complete Genome Sequence of Candida mucifera from an Otitis Media Patient

Rong-Chen Dai; Jing Guan; Ya-Ting Ning; Timothy Kudinha; Wei Zhang; Xin-Fei Chen; Ge Zhang; Ying-Chun Xu; Meng Xiao

doi:10.1007/s11046-024-00878-7

Complete Genome Sequence of Candida mucifera from an Otitis Media Patient

Mycopathologia. 2024 Sep 2;189(5):78. doi: 10.1007/s11046-024-00878-7.

Authors

Rong-Chen Dai^#^{1

2}, Jing Guan^#³, Ya-Ting Ning^{1

2}, Timothy Kudinha^{4

5}, Wei Zhang⁶, Xin-Fei Chen^{1

2}, Ge Zhang^{1

2}, Ying-Chun Xu^{7

8}, Meng Xiao^{9

10}

Affiliations

¹ Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
² Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, 100730, China.
³ Department of Laboratory Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.
⁴ School of Biomedical Sciences, Charles Sturt University, Orange, NSW, 2800, Australia.
⁵ NSW Health Pathology, Regional and Rural, Orange Hospital, Orange, NSW, 2800, Australia.
⁶ Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, Hebei, China.
⁷ Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. cjtcxiaomeng@aliyun.com.
⁸ Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, 100730, China. cjtcxiaomeng@aliyun.com.
⁹ Department of Laboratory Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. xycpumch@139.com.
¹⁰ Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, 100730, China. xycpumch@139.com.

^# Contributed equally.

PMID: 39222187
DOI: 10.1007/s11046-024-00878-7

Abstract

We describe for the first time, a high-quality genome for a rare human yeast pathogen Candida mucifera, from a patient with chronic suppurative otitis media. This pathogen exhibited reduced azole susceptibility, similar to its close relatives within the Trichomonascus ciferrii species complex.

Keywords: Candida mucifera; Fungal infection; Reduced azole susceptibility; Whole genome sequencing.

Publication types

Case Reports

MeSH terms

Antifungal Agents / pharmacology
Antifungal Agents / therapeutic use
Azoles / pharmacology
Candida* / classification
Candida* / genetics
Candida* / isolation & purification
Genome, Fungal*
Humans
Microbial Sensitivity Tests
Otitis Media* / microbiology
Sequence Analysis, DNA
Whole Genome Sequencing*

Substances

Antifungal Agents
Azoles

Grants and funding

2022YFC2303002/National Key Research and Development Program of China