Inhibition of Phagosome-Lysosome Fusion in Macrophages by Soluble Extracts of Virulent Brucella Abortus

Am J Vet Res. 1985 Feb;46(2):332-5.


Water extracts of virulent Brucella abortus were able to inhibit phagosome-lysosome fusion in unelicited murine peritoneal macrophages following ingestion of yeast. Extracts from an avirulent strain were unable to produce a similar effect. Lipopolysaccharide from B abortus did not appear to be involved with the ability of the extracts to inhibit fusion.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Allantois
  • Animals
  • Body Fluids / physiology
  • Brucella abortus / pathogenicity*
  • Lipopolysaccharides / pharmacology
  • Lysosomes / physiology*
  • Macrophages / physiology*
  • Membrane Fusion* / drug effects
  • Mice
  • Peritoneum / cytology
  • Phagocytosis
  • Saccharomyces cerevisiae / physiology
  • Virulence


  • Lipopolysaccharides