T6 antigen-positive cells in human labial salivary glands

Arch Oral Biol. 1985;30(4):325-9. doi: 10.1016/0003-9969(85)90005-6.

Abstract

The distribution of T6-positive cells in glands from three healthy individuals and 18 patients suffering from various systemic disorders was studied using OKT 6 and NA1/34 monoclonal antibodies in an indirect immunoperoxidase method on frozen sections. Although no positive cells were seen in the glands of healthy controls, 10 of the 18 biopsies from the patient-group contained T6-positive cells which were mostly within glandular epithelium. The presence of T6-positive cells appeared to correlate with lymphoid infiltration of the glands. Only one of the 8 patient biopsies showing normal or minimally-altered structure contained T6-positive cells. Thus these cells are unlikely to play a role in the normal physiological function of labial salivary glands.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface / analysis*
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Langerhans Cells / immunology
  • Lip / immunology
  • Male
  • Middle Aged
  • Salivary Glands / cytology
  • Salivary Glands / immunology*

Substances

  • Antibodies, Monoclonal
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface