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Review
. 2024 Aug 6;10(16):e35835.
doi: 10.1016/j.heliyon.2024.e35835. eCollection 2024 Aug 30.

Novel targets and improved immunotherapeutic techniques with an emphasis on antimycosal drug resistance for the treatment and management of mycosis

Affiliations
Review

Novel targets and improved immunotherapeutic techniques with an emphasis on antimycosal drug resistance for the treatment and management of mycosis

Riya Sarkar et al. Heliyon. .

Abstract

Infections due to pathogenic fungi are endemic in particular area with increased morbidity and mortality. More than a thousand people are infected per year and the way of treatment is of high demand having a significant impact on the population health. Medical practitioners confront various troublesome analytic and therapeutical challenges in the administration of immunosuppressed sufferer at high danger of expanding fungal infections. An upgraded antimycosal treatment is fundamental for a fruitful result while treating intrusive mycoses. A collection of antimycosal drugs keeps on developing with their specific antifungal targets including cell membrane, mitochondria, cell wall, and deoxyribonucleic acid (DNA)/ribonucleic acid (RNA) or protein biosynthesis. Some fundamental classes of ordinarily directed medications are the polyenes, amphotericin B, syringomycin, allylamines, honokiol, azoles, flucytosine, echinocandins etc. However, few immunotherapy processes and vaccinations are being developed to mark this need, although one presently can't seem to arrive at the conclusion. In this review article, there has been a trial to give details upgradation about the current immune therapeutic techniques and vaccination strategies against prevention or treatment of mycosis as well as the difficulties related with their turn of events. There has been also a visualization in the mentioned review paper about the various assorted drugs and their specific target analysis along with therapeutic interventions.

Keywords: CAR-T cell therapy; Candidiasis; Ergosterol; Fungal immunotherapy; Recombinant DNA vaccine.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Various resistance mechanisms of major antifungal drugs.
Fig. 2
Fig. 2
Overview of immunotherapy against mycoses.
Fig. 3
Fig. 3
Hematopoietic cell transplantation along with cells of the innate and adaptive immune systems in mycosis.
Fig. 4
Fig. 4
Different types of vaccination and their importance against mycosis.

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References

    1. Fernandes C.M., Poeta M.D. Fungal sphingolipids: role in the regulation of virulence and potential as targets for future antifungal therapies. Expert. Rev. Anti Infect. Ther. 2020;18(11):1083–1092. doi: 10.1080/14787210.2020.1792288. - DOI - PMC - PubMed
    1. Fuentefria A.M., Pippi B., Dalla Lanaet D.F., Donato K.K., de Andrade S.F. Antifungals discovery: an insight into new strategies to combat antifungal resistance. Lett. Appl. Microbiol. 2017;66(1):2–13. doi: 10.1111/lam.12820. - DOI - PubMed
    1. Perfect J.R. The antifungal pipeline: a reality check. Nat. Rev. Drug Discov. 2017;16(9):603–616. doi: 10.1038/nrd.2017.46. - DOI - PMC - PubMed
    1. McCaffrey S., Black R.A., Nagao M., Sepassi M., Sharma G., Thornton S., Kim Y.H., Braverman J. Measurement of quality of life in patients with mycosis fungoides/Sézary syndrome cutaneous T-cell lymphoma: development of an electronic instrument. J. Med. Internet Res. 2019;21(1) doi: 10.2196/11302. - DOI - PMC - PubMed
    1. Patterson T.F., Thompson G.R., III, Denning D.W., Fishman J.A., Hadley S., Herbrecht R., Kontoyiannis D.P., Marr K.A., Morrison V.A., Nguyen M.H., Segal B.H., Steinbach W.J., Stevens D.A., Walsh T.J.T., Wingard J.R., Young Jo-A.H., Bennett J.E. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the infectious diseases society of America. Clin. Infect. Dis. 2016;63(4):e1–e60. doi: 10.1093/cid/ciw326. - DOI - PMC - PubMed

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