Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Dec;21(12):e202401643.
doi: 10.1002/cbdv.202401643. Epub 2024 Oct 28.

Five Undescribed Sesquiterpenes with Anti-Inflammasome Activity Isolated from Saussurea Laniceps

Affiliations

Five Undescribed Sesquiterpenes with Anti-Inflammasome Activity Isolated from Saussurea Laniceps

Xuedan Zu et al. Chem Biodivers. 2024 Dec.

Abstract

Five previously undescribed guaialactone-type sesquiterpenes (1-5), called Lanicepsmines A-E, along with eleven know compounds (6-16), were isolated from the whole plant of Saussurea laniceps. NMR spectroscopic data analysis and MASS permitted the definition of their structures. The stereochemistry of the compounds was confirmed by ECD calculations. It is worth noting that compound 1 and 2 contain amino groups. Part of compounds were tested the anti-inflammasome activity, and compound 14 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC50 values of 0.698 μM.

Keywords: Anti-inflammasome activity; Saussurea laniceps; Sesquiterpenes.

PubMed Disclaimer

References

    1. L. B. Li, K. X. Cao, P. W. Tian, G. D. Xiao, R. S. Huang, Biochem. Syst. Ecol. 2019, 84, 37–41.
    1. L. M. Yang, H. B. Chen, Q. R. Guo, Acta Pharm. Sin. 2020, 55 (7), 1466–1477.
    1. J. J. Zhang, Y. J. Xu, R. Li, Y. Zhang, C. F. Yue, D. W. Bi, B. Cheng, X. W. Wu, R. H. Zhang, X. J. Zhang, A. F. Ainslides, Chem. Biodiversity 2022, 19 (5), e202200135.
    1. K. H. Lee, B. S. Kim, K. H. J. N. P. S. Rhee, Nat. Prod. Sci. 2017, 23 (4), 281–285.
    1. Q. L. Chen, X. Y. Chen, L. Zhu, H. B. Chen, H. M. Ho, W. P. Yeung, Z. Z. Zhao, T. J. P. R. Yi, Phytochem. Bioact. 2016, 15 (4), 537–565.

MeSH terms

LinkOut - more resources