Five Undescribed Sesquiterpenes with Anti-Inflammasome Activity Isolated from Saussurea Laniceps
- PMID: 39230656
- DOI: 10.1002/cbdv.202401643
Five Undescribed Sesquiterpenes with Anti-Inflammasome Activity Isolated from Saussurea Laniceps
Abstract
Five previously undescribed guaialactone-type sesquiterpenes (1-5), called Lanicepsmines A-E, along with eleven know compounds (6-16), were isolated from the whole plant of Saussurea laniceps. NMR spectroscopic data analysis and MASS permitted the definition of their structures. The stereochemistry of the compounds was confirmed by ECD calculations. It is worth noting that compound 1 and 2 contain amino groups. Part of compounds were tested the anti-inflammasome activity, and compound 14 exhibited potent activity and decreased LDH level in a dose-dependent manner, with IC50 values of 0.698 μM.
Keywords: Anti-inflammasome activity; Saussurea laniceps; Sesquiterpenes.
© 2024 Wiley-VHCA AG, Zurich, Switzerland.
References
-
- L. B. Li, K. X. Cao, P. W. Tian, G. D. Xiao, R. S. Huang, Biochem. Syst. Ecol. 2019, 84, 37–41.
-
- L. M. Yang, H. B. Chen, Q. R. Guo, Acta Pharm. Sin. 2020, 55 (7), 1466–1477.
-
- J. J. Zhang, Y. J. Xu, R. Li, Y. Zhang, C. F. Yue, D. W. Bi, B. Cheng, X. W. Wu, R. H. Zhang, X. J. Zhang, A. F. Ainslides, Chem. Biodiversity 2022, 19 (5), e202200135.
-
- K. H. Lee, B. S. Kim, K. H. J. N. P. S. Rhee, Nat. Prod. Sci. 2017, 23 (4), 281–285.
-
- Q. L. Chen, X. Y. Chen, L. Zhu, H. B. Chen, H. M. Ho, W. P. Yeung, Z. Z. Zhao, T. J. P. R. Yi, Phytochem. Bioact. 2016, 15 (4), 537–565.
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Grants and funding
- 22167021/National Natural Science Foundation of China
- 82260682/National Natural Science Foundation of China
- IRT_17R94/Program for Changjiang Scholars and Innovative Research Team in University
- 202101AT070195/Project of Innovative Research Team of Yunnan Province
- 202005AE160005/Project of Innovative Research Team of Yunnan Province
- Yun Ling Scholar Project to Wei-Lie Xiao
- 2019YFE0109200/National Key R&D Program of China
- 2022YKZY001/Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform
- 202101AY070001-289/Science and Technology Agency of Yunnan Province-Kunming Medical University Joint Fund
- Advanced Analysis and Measurement Center of Yunnan University
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