The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate

Scand J Clin Lab Invest. 1985 Apr;45(2):97-101. doi: 10.3109/00365518509160980.


The blood serum concentrations of creatinine and the low molecular weight proteins cystatin C, beta 2-microglobulin and retinol-binding protein were measured in 106 patients whose glomerular filtration rates were assessed by Cr-ethylenediaminetetraacetate (EDTA)-clearance determinations. The reciprocals of the serum concentrations of creatinine, cystatin C and beta 2-microglobulin were closely correlated to the Cr-EDTA-clearance (r = 0.73, 0.75 and 0.70, respectively) in contrast to the corresponding values for retinol-binding protein (r = 0.39). The calculated values of the glomerular elimination rate for creatinine and cystatin C were normally distributed in contrast to those for beta 2-microglobulin. The calculated glomerular elimination rate of cystatin C was not correlated to age, sex, type of disorder or disease activity. The results demonstrate that the serum level of cystatin C is a better measure of the glomerular filtration rate than the serum level of beta 2-microglobulin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Creatinine / blood
  • Cystatin C
  • Cystatins*
  • Edetic Acid
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Diseases / physiopathology
  • Male
  • Middle Aged
  • Protease Inhibitors / blood*
  • Proteins / analysis*
  • Retinol-Binding Proteins / analysis
  • Rheumatic Diseases / physiopathology
  • Urologic Diseases / physiopathology
  • beta 2-Microglobulin / analysis


  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • Protease Inhibitors
  • Proteins
  • Retinol-Binding Proteins
  • beta 2-Microglobulin
  • Edetic Acid
  • Creatinine