Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors

Abstract

Three distinct MN1::BEND2 fusion-positive tumors in pediatric patients. (A) Clinical course for each patient was variable in part due to differences in initial diagnosis. Each patient responded favorably to gross total resection and is stable at last follow-up. (B) Histologic diversity, lack of prominent classical astroblastoma features, and variable immunoexpression of key markers makes microscopic diagnosis challenging.

Keywords: MN1::BEND2 fusion; MN1‐altered; RNA sequencing; astroblastoma; ependymoma; pediatric.