Survey of Clinical Protocols for the Use of 177Lu-PSMA-617 in the United States

J Nucl Med Technol. 2024 Sep 5;52(3):208-211. doi: 10.2967/jnmt.123.266769.

Abstract

Although guidelines for the use of 177Lu-PSMA-617 published by various organizations are important, they do not include all the essential, practical points necessary for a complete institutional protocol. Therefore, a brief survey was performed to assess key components of the 177Lu-PSMA-617 protocol before, during, and after delivery of therapy. This survey demonstrated the wide variability in many aspects of institutional protocols regarding determination of eligibility for and administration of 177Lu-PSMA-617 therapy. The real-world protocol details provided here from a variety of institutions may help new and established theranostic programs.

Keywords: PSMA; lutetium; protocol; survey; theranostics.

MeSH terms

  • Clinical Protocols*
  • Dipeptides* / therapeutic use
  • Heterocyclic Compounds, 1-Ring*
  • Humans
  • Lutetium*
  • Prostate-Specific Antigen
  • Prostatic Neoplasms / radiotherapy
  • Surveys and Questionnaires
  • United States

Substances

  • Dipeptides
  • Heterocyclic Compounds, 1-Ring
  • Lutetium
  • Pluvicto
  • Prostate-Specific Antigen