Heterochromatin: Hiding from the remodeling machines

Mol Cell. 2024 Sep 5;84(17):3167-3169. doi: 10.1016/j.molcel.2024.08.012.

Abstract

In this issue of Molecular Cell, Sahu et al.1 find that shielding heterochromatin from SWI/SNF chromatin remodelers is essential to maintain and epigenetically propagate pre-existing heterochromatin domains, whereas SWI/SNF action protects facultative heterochromatic regions from premature silencing.

MeSH terms

  • Chromatin Assembly and Disassembly*
  • Chromosomal Proteins, Non-Histone* / genetics
  • Chromosomal Proteins, Non-Histone* / metabolism
  • Epigenesis, Genetic
  • Gene Silencing
  • Heterochromatin* / genetics
  • Heterochromatin* / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Chromosomal Proteins, Non-Histone
  • Heterochromatin
  • SWI-SNF-B chromatin-remodeling complex
  • Transcription Factors