Heterogeneity in Keloid Scars: Influence of Mechanical Stretching on Keloids Arising from Different Anatomical Sites

J Invest Dermatol. 2025 Mar;145(3):710-713.e7. doi: 10.1016/j.jid.2024.08.016. Epub 2024 Sep 6.

¹ Department of Dermatology, Yonsei University College of Medicine, Seoul, Republic of Korea; Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Seoul, Republic of Korea.
² Bioinformatics Collaboration Unit, Yonsei Biomedical Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
³ Department of Dermatology, Yonsei University College of Medicine, Seoul, Republic of Korea; Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
⁴ Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.
⁵ Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Seoul, Republic of Korea; Department of Plastic Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
⁶ Department of Dermatology, Yonsei University College of Medicine, Seoul, Republic of Korea; Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: DYKIM@yuhs.ac.
⁷ Department of Dermatology, Yonsei University College of Medicine, Seoul, Republic of Korea; Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea; Scar Laser and Plastic Surgery Center, Yonsei Cancer Hospital, Seoul, Republic of Korea. Electronic address: juhee@yuhs.ac.

No abstract available

Keywords: Fibroblasts; Heterogeneity; Keloid scars; Single-cell RNA sequencing; Stretch.