Localization of the gene encoding the human interleukin-2 receptor on chromosome 10

Science. 1985 Jun 28;228(4707):1547-9. doi: 10.1126/science.3925551.

Abstract

The human interleukin-2 receptor is an inducible growth factor receptor present on the surface of activated T lymphocytes. The receptor is required for a normal T-cell immune response. High-resolution fluorescence-activated chromosome sorting and DNA spot-blot analysis with complementary DNA's for the interleukin-2 receptor indicated that the receptor gene was located on chromosome 9, 10, 11, or 12. In situ hybridization studies showed that the interleukin-2 receptor gene is on the short arm of chromosome 10, p14----15.

MeSH terms

  • Cell Line
  • Chromosomes, Human, 6-12 and X*
  • DNA / analysis
  • Humans
  • Lymphocyte Activation
  • Male
  • Nucleic Acid Hybridization
  • Phytohemagglutinins / pharmacology
  • Receptors, Immunologic / genetics*
  • Receptors, Interleukin-2
  • T-Lymphocytes / analysis
  • T-Lymphocytes / immunology

Substances

  • Phytohemagglutinins
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • DNA