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. 2024 Dec 16;19(24):e202400313.
doi: 10.1002/cmdc.202400313. Epub 2024 Nov 5.

Flavonol-Ruthenium Complexes as Antioxidant and Anticancer Agents

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Flavonol-Ruthenium Complexes as Antioxidant and Anticancer Agents

Ting-Wei Wu et al. ChemMedChem. .

Abstract

Flavonol-metal complexes can enhance the biological activity of flavonols. Inspired by the potential of ruthenium-based drugs in pharmaceutical applications, seven flavonol-Ru (II) complexes were synthesized to evaluate their biological activities. Among these compounds, compounds 8, 11, and 12 showed potent antioxidant activities. Compound 12 exhibited superior anti-inflammatory activity to natural quercetin, which served as a positive control. This study is the first to report the free radical scavenging abilities and antioxidant activity of flavonol-Ru (II) complexes. Furthermore, compound 12 demonstrated comparable efficacy to 5-FU against human non-small-cell lung cancer cells (A549). These results strongly support the potential of flavonol-Ru (II) agents.

Keywords: Anti-inflammatory; Anticancer; Antioxidant; Flavonol; Flavonol-ruthenium complexes.

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