Postoperative exacerbated cough hypersensitivity syndrome induces dramatic respiratory alkalosis, lactatemia, and electrolyte imbalance

BMC Anesthesiol. 2024 Sep 11;24(1):323. doi: 10.1186/s12871-024-02695-3.

Abstract

Background: The perioperative management of patients with chronic cough or cough hypersensitivity syndrome and its sometimes severe effects is currently under-researched and under-reported.

Case presentation: A 46-year-old female patient with a history of chronic cough and Cough Hypersensitivity Syndrome. After laparoscopic hiatoplasty and anterior fundoplication under general anesthesia, experienced a pronounced exacerbation of coughing symptoms. Despite prompt and extensive treatment involving antitussives, inhalants, anxiolytics, and sedatives, the symptoms remained uncontrollable. Within a few hours, the patient developed a respiratory alkalosis with severe and life-threatening electrolyte shift (pH 7.705, pCO2 1.72 kPa, K+ 2.1 mmol/l). Lactatemia lasted for more than 12 hours with values up to 6.6 mmol/l. Acute bleeding, pneumothorax, and an acute cardiac event were ruled out. Deep analgosedation and inhalation of high-percentage local anesthetics were necessary to manage the clinical symptoms.

Conclusions: This case highlights the challenging nature of chronic cough and hypersensitivity syndrome perioperatively. A tailored anesthesiologic approach, exclusion of other provoking medical problems, and knowledge of possible management and treatment options are key.

Keywords: Lactatemia; Postoperative cough; Recovery room; Respiratory alkalosis.

Publication types

  • Case Reports

MeSH terms

  • Alkalosis, Respiratory*
  • Anesthesia, General / adverse effects
  • Anesthesia, General / methods
  • Cough*
  • Female
  • Fundoplication / adverse effects
  • Humans
  • Hyperlactatemia
  • Middle Aged
  • Postoperative Complications*
  • Respiratory Tract Diseases
  • Syndrome
  • Water-Electrolyte Imbalance

Supplementary concepts

  • cough hypersensitivity syndrome