ObjectiveDietary habits have long been known to be a critical factor influencing cognitive health, especially among older adults. Despite extensive research on various dietary supplements, the impact of omega-3 polyunsaturated fatty acids (PUFAs) on cognitive function has not yet been thoroughly investigated. This research seeks to determine whether taking more omega-3 PUFAs correlates with improved cognitive function in older adults.MethodsCross-sectional data were analyzed from the National Health and Nutrition Examination Survey (NHANES), which included 2430 elderly participants aged 60 and above in the United States. The association between omega-3 consumption and cognitive outcomes was evaluated using linear regression models. Smoothing curves and threshold effect analysis were employed to examine nonlinear associations. Subgroup studies were conducted to demonstrate the strength and reliability of the association and factors affecting it.ResultsThe fully adjusted model demonstrated significant positive correlations between omega-3 intake and scores on all 3 cognitive assessments. Specifically, in the final model, the beta coefficients for the CERAD Word Learning test, Animal Fluency Test, and Digit Symbol Substitution Test were 0.53 (95% CI: 0.33-0.72, P < 0.0001), 0.29 (95% CI: 0.12-0.47, P = 0.001), and 0.61 (95% CI: 0.19-1.03, P = 0.0045), respectively.ConclusionIncreased intake of omega-3 was positively and independently associated with cognitive function in older adults, suggesting that consumption of omega-3 PUFAs may help to prevent cognitive decline with aging. Prospective studies are needed to determine the direct of effect in this association.
Keywords: NHANES; PUFAs; cognitive function; omega-3.