Monotherapy and polytherapy for intractable epilepsies

Ital J Neurol Sci. 1985 Jun;6(2):201-5. doi: 10.1007/BF02229193.

Abstract

A retrospective survey on 66 adults with epilepsy who received multiple drug therapy after the failure of single drugs showed: a reduction of seizure frequency of 75% or more in 16.5%, no change in 67% and an increase in seizure frequency of 100% or more in 16.5%. Multiple drug therapy is of limited value in severe epilepsies.

MeSH terms

  • Anti-Anxiety Agents*
  • Anticonvulsants / therapeutic use*
  • Benzodiazepines*
  • Benzodiazepinones / therapeutic use
  • Carbamazepine / therapeutic use
  • Clobazam
  • Drug Therapy, Combination
  • Epilepsy / drug therapy*
  • Female
  • Humans
  • Male
  • Phenobarbital / therapeutic use
  • Phenytoin / therapeutic use
  • Primidone / therapeutic use
  • Valproic Acid / therapeutic use

Substances

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Benzodiazepinones
  • Benzodiazepines
  • Primidone
  • Clobazam
  • Carbamazepine
  • Valproic Acid
  • Phenytoin
  • Phenobarbital