Effect of 1,25-dihydroxyvitamin D3 and nifedipine on prolactin release in normal man

J Endocrinol Invest. 1985 Apr;8(2):103-6. doi: 10.1007/BF03350657.

Abstract

In normal man 1,25 (OH)2-vitamin D3 [1,25 (OH)2D] increases both basal and TRH-stimulated prolactinemia; this effect is completely reversible by the calcium antagonist nifedipine. Similarly the 1,25 (OH)2D-induced hypercalcemia is totally inhibited by nifedipine. These findings suggest that both biological effects of 1,25 (OH)2D are mediated by calcium-dependent mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Calcitriol / pharmacology*
  • Calcium / blood
  • Humans
  • Male
  • Nifedipine / pharmacology*
  • Prolactin / blood*
  • Thyrotropin-Releasing Hormone / pharmacology

Substances

  • Thyrotropin-Releasing Hormone
  • Prolactin
  • Calcitriol
  • Nifedipine
  • Calcium