Nutritional nystagmus in infants

J Pediatr Ophthalmol Strabismus. 1985 Jul-Aug;22(4):140-2. doi: 10.3928/0191-3913-19850701-08.


Two infants presented with acquired infantile nystagmus. On examination, they manifested peculiar facies, growth and developmental delay, failure to thrive, and a Wernicke's type of nystagmus. Suspicion of a B vitamin deficiency resulted in correct diagnosis of dietary deficiency and/or enzymatic defect. In both instances, dietary treatment with B vitamins resulted in resolution of the nystagmus and improved growth and development of both individuals. Physicians, especially pediatricians and ophthalmologists, should be alert to the possibility of a Wernicke's type nystagmus in such infants, since the diagnosis may be critical to accurate diagnosis and treatment.

Publication types

  • Case Reports

MeSH terms

  • Biotin / deficiency
  • Biotin / therapeutic use
  • Humans
  • Infant
  • Male
  • Nutrition Disorders / complications*
  • Nystagmus, Pathologic / diagnostic imaging
  • Nystagmus, Pathologic / drug therapy
  • Nystagmus, Pathologic / etiology*
  • Pyruvate Dehydrogenase Complex Deficiency Disease
  • Thiamine / therapeutic use
  • Tomography, X-Ray Computed


  • Biotin
  • Thiamine