Evidence for an anticomplementary factor associated with human bone marrow cells

J Natl Cancer Inst. 1985 Sep;75(3):441-5.

Abstract

Complement (C)-mediated lysis of antibody-sensitized sheep erythrocytes was inhibited by the addition of human bone marrow cells. The anticomplementary activity could be attributed to a soluble factor that was released from the bone marrow cells. This factor inhibited at an early stage in the C-cascade and showed the characteristics of a factor that accelerates decay of C2. The release of such a factor by bone marrow cells would present an obstacle to the use of antibody and C to purge tumor cells from bone marrow that is to be used for autologous transplantation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bone Marrow / physiology*
  • Bone Marrow Transplantation
  • Complement Inactivator Proteins / biosynthesis
  • Complement Inactivator Proteins / physiology*
  • Complement System Proteins / immunology
  • Cytotoxicity, Immunologic
  • Edetic Acid / pharmacology
  • Erythrocytes / immunology
  • Humans
  • Kinetics
  • Mice
  • Mice, Inbred BALB C
  • Rabbits

Substances

  • Complement Inactivator Proteins
  • Complement System Proteins
  • Edetic Acid