In laser induced wounds of myocardium and liver of rats, 1 reversible zone and 3 irreversible zones of damage can be separated in dependence of time until 24 h by a combined enzyme-histochemical and fluorescence microscopical technique. Besides these zones, another carbonized zone is also detectable. A mainly reversible zone of contraction can be seen for a short time in the myocardium. The results indicate different types of manifestation of laser and ischemic induced tissue necroses.