Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin

Maria Antonietta Casulli; Ruyu Yan; Satomi Takeuchi; Andrea Cesari; Fabrizio Mancin; Takashi Hayashita; Takeshi Hashimoto; Irene Taurino

doi:10.1021/acsanm.4c02972

Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin

ACS Appl Nano Mater. 2024 Aug 27;7(17):20153-20162. doi: 10.1021/acsanm.4c02972. eCollection 2024 Sep 13.

Authors

Maria Antonietta Casulli¹, Ruyu Yan², Satomi Takeuchi², Andrea Cesari^{3

4}, Fabrizio Mancin⁴, Takashi Hayashita², Takeshi Hashimoto², Irene Taurino^{1

5}

Affiliations

¹ Micro and Nano-Systems (MNS), Department of Electrical Engineering (ESAT), Katholieke Universiteit Leuven (KU Leuven), 3001 Leuven, Belgium.
² Graduate School of Science and Technology, Department of Materals and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-cho, Chiyoda-ku, Tokyo 102-8554, Japan.
³ Department of Chemistry and Industrial Chemistry, University of Pisa, via G. Moruzzi 13, 56124 Pisa, Italy.
⁴ Department of Chemical Sciences, University of Padova, via Marzolo 1, 35131 Padova, Italy.
⁵ Semiconductor Physics (HF), Department of Physics and Astronomy, Katholieke Universiteit Leuven (KU Leuven), 3001 Leuven, Belgium.

Abstract

Curcumin (CUR), a polyphenolic substance from turmeric, displays diverse medicinal properties. However, its instability poses challenges in detection. Cyclodextrin-based nanogels (CyDngs) offer a transformative solution, enhancing CUR's stability in aqueous solutions. Multisensing approaches involving fluorescence, electrochemistry, and NMR spectroscopy were employed, demonstrating CyDngs' pivotal role in CUR detection. Langmuir analysis revealed a binding constant of 1.4 × 10⁴ M^-1 for CyDngs, highlighting their effectiveness over native β-CyDs. The study emphasized CyDngs' superiority in stabilizing CUR and enabling reliable and sensitive detection with very diverse methods.