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. 2025 Jan;22(1):e202401597.
doi: 10.1002/cbdv.202401597. Epub 2024 Nov 4.

p-Terphenyl and Orsellinic Acid Derivatives from the European Polyporales Terana coerulea and Sparassis brevipes

Affiliations

p-Terphenyl and Orsellinic Acid Derivatives from the European Polyporales Terana coerulea and Sparassis brevipes

Winnie Chemutai Sum et al. Chem Biodivers. 2025 Jan.

Abstract

Investigation of the secondary metabolites of the solid-state rice cultures from the European basidiomycetes Terana coerulea and Sparassis brevipes afforded three previously undescribed secondary metabolites identified as two p-terphenyl derivatives (1 and 2) and one orsellinic acid congener (3) in addition to another known, isoeverninic acid (4). Chemical structures of the isolated compounds were elucidated through comprehensive 1D and 2D NMR spectroscopic analyses, coupled with HR-MS and other spectral methods. The isolated compounds were assessed for their cytotoxic and antimicrobial activities. Compound 1 revealed weak antimicrobial properties, whereas the inseparable mixture of 3 and 4 featured moderate cytotoxic and antimicrobial effects.

Keywords: Corticin; Corticium caeruleum; Lichen depsides; Orsellinic acid; Sparassis brevipes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of 14.
Figure 2
Figure 2
Key 1H−1H COSY, HMBC and ROESY correlations of 1–3.

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