Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial

doi:10.1001/jamaoncol.2024.4000

. 2024 Sep 19;10(11):1590-1593.

doi: 10.1001/jamaoncol.2024.4000. Online ahead of print.

Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial

Jim C Hu¹, Melissa Assel², Mohammad E Allaf³, Andrew J Vickers², Behfar Ehdaie⁴, Andrew J Cohen³, David A Green⁵, Ahmed Ghazi³, Benjamin T Ristau⁶, Keith J Kowalczyk⁷, Arvin K George³, Hiten D Patel⁸, Jeffrey S Montgomery⁹, Misop Han³, Michael Rezaee³, Christian P Pavlovich³, Neal A Patel⁵, Ashley E Ross⁸, Shilajit D Kundu⁸, Gerald J Wang⁵, Jonathan E Shoag¹⁰, Nirmish Singla³, Kristian Stensland⁹, Michael A Gorin¹¹, Anthony J Schaeffer⁸, Edward M Schaeffer⁸

Affiliations

¹ Brady Department of Urology, New York Presbyterian Weill Cornell Medicine Hospital, New York.
² Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
³ James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
⁴ Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
⁵ Brady Department of Urology, New York Presbyterian Weill Cornell Medicine Queens, New York.
⁶ Department of Surgery, Division of Urology, UConn Health, Farmington, Connecticut.
⁷ Department of Urology, MedStar Georgetown University Hospital, Washington, DC.
⁸ Department of Urology, Northwestern University, Chicago, Illinois.
⁹ Department of Urology, Michigan Medicine, Ann Arbor.
¹⁰ Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹¹ Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.

PMID: 39298143
PMCID: PMC11413751 (available on 2025-09-19)
DOI: 10.1001/jamaoncol.2024.4000

Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial

Jim C Hu et al. JAMA Oncol. 2024.

. 2024 Sep 19;10(11):1590-1593.

doi: 10.1001/jamaoncol.2024.4000. Online ahead of print.

Authors

Affiliations

¹ Brady Department of Urology, New York Presbyterian Weill Cornell Medicine Hospital, New York.
² Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
³ James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
⁴ Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.
⁵ Brady Department of Urology, New York Presbyterian Weill Cornell Medicine Queens, New York.
⁶ Department of Surgery, Division of Urology, UConn Health, Farmington, Connecticut.
⁷ Department of Urology, MedStar Georgetown University Hospital, Washington, DC.
⁸ Department of Urology, Northwestern University, Chicago, Illinois.
⁹ Department of Urology, Michigan Medicine, Ann Arbor.
¹⁰ Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
¹¹ Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York.

PMID: 39298143
PMCID: PMC11413751 (available on 2025-09-19)
DOI: 10.1001/jamaoncol.2024.4000

No abstract available

Plain language summary

This randomized clinical trial compares the effect of transperineal vs transrectal prostate biopsy on infection rates after biopsy.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Vickers reported receiving personal fees from Arctic Partners, receiving royalties from Opko for the 4Kscore test, and having stock options in Opko. Dr George reported receiving personal fees from CIVCO Medical Instruments and BK Medical. Dr Shoag reported receiving grants from the Bristol Myers Squibb Foundation and receiving personal fees from Fortec Medical. Dr Gorin reported receiving personal fees from Perineologic and KOELIS Inc. No other disclosures were reported.

References

1. Hu JC, Assel M, Allaf ME, et al. . Transperineal versus transrectal magnetic resonance imaging–targeted and systematic prostate biopsy to prevent infectious complications: the PREVENT randomized trial. Eur Urol. 2024;86(1):61-68. doi:10.1016/j.eururo.2023.12.015 - DOI - PubMed
1. Gandaglia G, Leni R, Bray F, et al. . Epidemiology and prevention of prostate cancer. Eur Urol Oncol. 2021;4(6):877-892. doi:10.1016/j.euo.2021.09.006 - DOI - PubMed
1. Castellani D, Pirola GM, Law YXT, et al. . Infection rate after transperineal prostate biopsy with and without prophylactic antibiotics: results from a systematic review and meta-analysis of comparative studies. J Urol. 2022;207(1):25-34. doi:10.1097/JU.0000000000002251 - DOI - PubMed
1. Mian BM, Feustel PJ, Aziz A, et al. . Complications following transrectal and transperineal prostate biopsy: results of the ProBE-PC randomized clinical trial. J Urol. 2024;211(2):205-213. doi:10.1097/JU.0000000000003788 - DOI - PubMed
1. Liss MA, Ehdaie B, Loeb S, et al. . An update of the American Urological Association white paper on the prevention and treatment of the more common complications related to prostate biopsy. J Urol. 2017;198(2):329-334. doi:10.1016/j.juro.2017.01.103 - DOI - PubMed

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[1] Hu JC, Assel M, Allaf ME, et al. . Transperineal versus transrectal magnetic resonance imaging–targeted and systematic prostate biopsy to prevent infectious complications: the PREVENT randomized trial. Eur Urol. 2024;86(1):61-68. doi:10.1016/j.eururo.2023.12.015 - DOI - PubMed

[2] Hu JC, Assel M, Allaf ME, et al. . Transperineal versus transrectal magnetic resonance imaging–targeted and systematic prostate biopsy to prevent infectious complications: the PREVENT randomized trial. Eur Urol. 2024;86(1):61-68. doi:10.1016/j.eururo.2023.12.015 - DOI - PubMed

[3] Gandaglia G, Leni R, Bray F, et al. . Epidemiology and prevention of prostate cancer. Eur Urol Oncol. 2021;4(6):877-892. doi:10.1016/j.euo.2021.09.006 - DOI - PubMed

[4] Gandaglia G, Leni R, Bray F, et al. . Epidemiology and prevention of prostate cancer. Eur Urol Oncol. 2021;4(6):877-892. doi:10.1016/j.euo.2021.09.006 - DOI - PubMed

[5] Castellani D, Pirola GM, Law YXT, et al. . Infection rate after transperineal prostate biopsy with and without prophylactic antibiotics: results from a systematic review and meta-analysis of comparative studies. J Urol. 2022;207(1):25-34. doi:10.1097/JU.0000000000002251 - DOI - PubMed

[6] Castellani D, Pirola GM, Law YXT, et al. . Infection rate after transperineal prostate biopsy with and without prophylactic antibiotics: results from a systematic review and meta-analysis of comparative studies. J Urol. 2022;207(1):25-34. doi:10.1097/JU.0000000000002251 - DOI - PubMed

[7] Mian BM, Feustel PJ, Aziz A, et al. . Complications following transrectal and transperineal prostate biopsy: results of the ProBE-PC randomized clinical trial. J Urol. 2024;211(2):205-213. doi:10.1097/JU.0000000000003788 - DOI - PubMed

[8] Mian BM, Feustel PJ, Aziz A, et al. . Complications following transrectal and transperineal prostate biopsy: results of the ProBE-PC randomized clinical trial. J Urol. 2024;211(2):205-213. doi:10.1097/JU.0000000000003788 - DOI - PubMed

[9] Liss MA, Ehdaie B, Loeb S, et al. . An update of the American Urological Association white paper on the prevention and treatment of the more common complications related to prostate biopsy. J Urol. 2017;198(2):329-334. doi:10.1016/j.juro.2017.01.103 - DOI - PubMed

[10] Liss MA, Ehdaie B, Loeb S, et al. . An update of the American Urological Association white paper on the prevention and treatment of the more common complications related to prostate biopsy. J Urol. 2017;198(2):329-334. doi:10.1016/j.juro.2017.01.103 - DOI - PubMed

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Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial

Affiliations

Transperineal vs Transrectal Prostate Biopsy-The PREVENT Randomized Clinical Trial

Authors

Affiliations

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Conflict of interest statement

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References

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Plain language summary

Conflict of interest statement

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