Breakage on chromosome 2 brings the Ck gene to a region 3' of c-myc in a Burkitt's lymphoma line carrying a (2;8) translocation

Cytogenet Cell Genet. 1985;39(3):168-72. doi: 10.1159/000132129.

Abstract

We have shown using in situ hybridization that the constant region of the kappa light chain immunoglobulin gene (Ck) is translocated from chromosome 2 to chromosome 8 in Burkitt's lymphoma cells with a (2;8) translocation. The Ck gene then ends up adjacent to and on the 3' side of c-myc. The breakpoint probably falls between the gene for the variable region of the kappa light chain (Vk) and the Ck gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Burkitt Lymphoma / genetics*
  • Burkitt Lymphoma / immunology
  • Cell Line
  • Chromosome Banding
  • Chromosomes, Human, 1-3*
  • Chromosomes, Human, 6-12 and X*
  • Genes*
  • Humans
  • Immunoglobulin Light Chains / genetics*
  • Immunoglobulin kappa-Chains / genetics*
  • Nucleic Acid Hybridization
  • Oncogenes*
  • Translocation, Genetic*

Substances

  • Immunoglobulin Light Chains
  • Immunoglobulin kappa-Chains