Abstract
We have shown using in situ hybridization that the constant region of the kappa light chain immunoglobulin gene (Ck) is translocated from chromosome 2 to chromosome 8 in Burkitt's lymphoma cells with a (2;8) translocation. The Ck gene then ends up adjacent to and on the 3' side of c-myc. The breakpoint probably falls between the gene for the variable region of the kappa light chain (Vk) and the Ck gene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Burkitt Lymphoma / genetics*
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Burkitt Lymphoma / immunology
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Cell Line
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Chromosome Banding
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Chromosomes, Human, 1-3*
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Chromosomes, Human, 6-12 and X*
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Genes*
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Humans
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Immunoglobulin Light Chains / genetics*
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Immunoglobulin kappa-Chains / genetics*
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Nucleic Acid Hybridization
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Oncogenes*
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Translocation, Genetic*
Substances
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Immunoglobulin Light Chains
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Immunoglobulin kappa-Chains