The Amino Acid Sequence of the Zinc-Requiring Beta-Lactamase II From the Bacterium Bacillus Cereus 569

FEBS Lett. 1985 Sep 23;189(2):207-11. doi: 10.1016/0014-5793(85)81024-3.

Abstract

The amino acid sequence of the zinc-requiring beta-lactamase II from Bacillus cereus strain 569 has been determined. It consists of a single polypeptide chain of 227 residues. It is the only example so far fully characterized of a class B beta-lactamase, and is structurally and mechanistically distinct from both the widely distributed class A beta-lactamases (such as the Escherichia coli RTEM enzyme) and from the chromosomally encoded class C enzymes from Gram-negative bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacillus cereus / enzymology*
  • Cephalosporinase / analysis*
  • Cyanogen Bromide / pharmacology
  • Peptide Fragments / analysis
  • Zinc / metabolism*
  • beta-Lactamases / analysis*

Substances

  • Peptide Fragments
  • Cephalosporinase
  • beta-Lactamases
  • Zinc
  • Cyanogen Bromide