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. 2024 Dec:179:106217.
doi: 10.1016/j.fitote.2024.106217. Epub 2024 Sep 18.

Bioactive abietenolide diterpenes from Suregada procera

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Free article

Bioactive abietenolide diterpenes from Suregada procera

Jackson Obegi Matundura et al. Fitoterapia. 2024 Dec.
Free article

Abstract

The phytochemical investigation of the leaves and the roots of Suregada procera afforded the new ent-abietane diterpenoid sureproceriolide A (1) along with the known secondary metabolites 8,14β:11,12α-diepoxy-13(15)-abietane-16,12-olid (2), jolkinolide A (3), jolkinolide E (4), ent-pimara-8(14),15-dien-19-oic acid (5), sitosterol (6), oleana-9(11):12-dien-3β-ol (7), and oleic acid (8). Their structures were elucidated by NMR spectroscopic and mass spectrometric analyses, and the structure of jolkinolide A (3) was confirmed by single-crystal X-ray diffraction analysis. Sureproceriolide A (1) showed modest activity against the Gram-positive bacterium Staphylococcus lugdunensis (MIC = 31.44 μM), and sitosterol (6) against the Gram-negative bacterium Porphyromonas gingivalis (IC50 = 45.37 μM). Jolkinolide A (3) and E (4) as well as sitosterol (6) inhibited the release of NOS (IMR-90 cells), TNF-α (HaCaT cells) and NF-κB (HaCaT cells), with IC50 values of 0.43, 3.21, and 10.32 μM, respectively. Compound 6 showed antitumoral activity against SK-MEL-28 (IC50 = 20.66 μM) and CCD-13Lu (IC50 = 24.70 μM) cell lines, with no cytotoxic effect against the prostate cells PrEC (CC50 > 300 μM).

Keywords: Abietanolide; Anti-inflammatory; Antibacterial; Antitumoral; Euphorbiaceae; Suregada procera.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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