Dinoflagellate mRNA is pervasively modified with m1A

EMBO Rep. 2024 Nov;25(11):4634-4635. doi: 10.1038/s44319-024-00263-x. Epub 2024 Sep 20.

Abstract

N1-methyladenosine (m1A) is a very rare RNA modification in mammalian mRNA, which occurs in sequences resembling the T-loop of tRNAs and may not have significant effects on gene expression. A new study in this issue now reports that m1A is abundant and dynamic in the 3′UTR of mRNAs of dinoflagellates, and could have an important role in post-transcriptional gene expression regulation in these organisms.