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. 2024 Sep;49(17):4695-4701.
doi: 10.19540/j.cnki.cjcmm.20240607.201.

[Chemical constituents of Viburnum utile and their inhibitory activities against α-glucosidase]

[Article in Chinese]
Affiliations

[Chemical constituents of Viburnum utile and their inhibitory activities against α-glucosidase]

[Article in Chinese]
Chu-Yi Long et al. Zhongguo Zhong Yao Za Zhi. 2024 Sep.

Abstract

The chemical constituents in the ethanol extract of Viburnum utile were isolated by column chromatography with D101 macroporous resin, silica gel, and Sephadex LH-20. Their structures were identified by spectroscopic techniques such as NMR and MS. All the compounds were evaluated for the inhibitory activities against α-glucosidase. Sixteen compounds were obtained and identified as viburnumide A(1), vitamin E(2), α-amyrin(3), α-tocoquinone(4), narjatamanin B(5), ethyl caffeate(6), naringenin(7), apigenin(8), ethyl β-D-ribo-hex-3-ulopyranoside(9), trans-p-hydroxycinnamic acid(10), amentoflavone(11), apigenin-7-O-β-D-glucoside(12), luteolin-7-O-β-D-glucoside(13), henryoside(14), ursolic acid(15), and 2α-hydroxy-oleanolic acid(16). Among them, compound 1 was a new compound, and compounds 2-16 were isolated from V. utile for the first time. The inhibitory activity(IC_(50) of 4.0 μmol·L~(-1)) of compound 11 against α-glucosidase was comparable to that of the positive control acarbose(IC_(50) of 2.3 μmol·L~(-1)).

Keywords: Viburnum utile; chemical constituents; inhibitory activity against α-glucosidase; viburnumide A.

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