Calcium oscillations and mitochondrial enzymes in stem cells

Mio Fukuoka; Woojin Kang; Sae Horiike; Mitsutoshi Yamada; Kenji Miyado

doi:10.1016/j.reth.2024.09.002

Calcium oscillations and mitochondrial enzymes in stem cells

Regen Ther. 2024 Sep 14:26:811-818. doi: 10.1016/j.reth.2024.09.002. eCollection 2024 Jun.

Authors

Mio Fukuoka^{1

2}, Woojin Kang^{2

3}, Sae Horiike^{2

4}, Mitsutoshi Yamada¹, Kenji Miyado^{2

5}

Affiliations

¹ Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
² Department of Reproductive Biology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
³ Laboratory Animal Resource Center, Transborder Medical Research Center, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
⁴ Department of Bioscience, Graduate School of Life Science, Tokyo University of Agriculture, Setagaya-ku, Tokyo, Japan.
⁵ Division of Diversity Research, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.

Abstract

Calcium oscillations are rhythmic fluctuations of the intracellular concentration of calcium ions (Ca²⁺). As Ca²⁺ evokes various cellular processes, its intracellular concentration is tightly regulated. Ca²⁺ oscillations control biological events, including neuronal differentiation and proliferation of mesenchymal stem cells. The frequency and pattern of Ca²⁺ oscillations depend on cell type. Researchers have studied Ca²⁺ oscillations to better understand how cells communicate and regulate physiological processes. Dysregulation of Ca²⁺ oscillations causes health problems, such as neurodegenerative disorders. This review discusses the potential functions of Ca²⁺ oscillations in stem cells.

Keywords: Calcium oscillations; Citrate synthase; Mitochondria; Stem cells.

Publication types

Review