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. 2024 Oct;32(10):1967-1974.
doi: 10.1002/oby.24130.

Obesity increases the risk of hepatic fibrosis in young adults with type 2 diabetes mellitus: the need to screen

Anu Sharma  1 , Eddison Godina Leiva  1 , Srilaxmi Kalavalapalli  1 , Romina Lomonaco  1 , Stephen A Marangi  1 , Enrique Valdez Saenz  1 , Maria A Gonzalez  1 , Andrea Ortiz Rocha  1 , Nathaly Cuervo Pardo  1 , Jens Rosenberg  2 , Pierre Bedossa  3 , Fernando Bril  1 , Diana Barb  1 , Kenneth Cusi  1
Affiliations

Obesity increases the risk of hepatic fibrosis in young adults with type 2 diabetes mellitus: the need to screen

Anu Sharma et al. Obesity (Silver Spring). 2024 Oct.

Erratum in

Abstract

Objective: The objective of this study was to determine the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in young compared with older adults.

Methods: Individuals (n = 1420) with (63%) and without type 2 diabetes mellitus (T2D; 37%) who attended internal medicine clinics and did not have a known history of MASLD underwent laboratory evaluation and transient elastography to assess for hepatic steatosis and fibrosis. Magnetic resonance elastography and liver biopsy were recommended when indicated.

Results: A total of 243 participants were ages <45 years, and 1177 were ages ≥45 years. Obesity, T2D, and metabolic syndrome were highly prevalent in young adults. Frequencies of steatosis and fibrosis were high in young adults (50.2% and 7.5% vs. older adults 52.7% and 9.9%, respectively) and were significantly higher in those with both obesity and T2D (71.1% and 15.7%, respectively; p < 0.01). In young adults, T2D and obesity were the strongest risk factors for hepatic fibrosis (odds ratios 4.33 [95% CI: 1.37-13.68] and 1.16 [95% CI: 1.07-1.25], respectively; p < 0.05).

Conclusions: There is a high prevalence of clinically significant hepatic fibrosis in young adults with cardiometabolic risk factors. Up to one in seven young adults with obesity and T2D had clinically significant hepatic fibrosis on elastography. This highlights the need to screen young adults with cardiometabolic risk factors for MASLD for early detection and intervention.

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References

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