The breakpoint in 22q11 in a case of Ph-positive acute lymphocytic leukemia interrupts the immunoglobulin light chain gene cluster

Cancer Genet Cytogenet. 1985 Oct;18(2):173-7. doi: 10.1016/0165-4608(85)90067-6.

Abstract

With a constant region probe (c-lambda) from the immunoglobulin light chain gene cluster, we performed in situ hybridization to bone marrow chromosome preparations from a patient with a Ph-positive form of acute lymphocytic leukemia. Results in this patient indicate that the immunoglobulin chain genes were involved in the 9;22 chromosome rearrangement.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, 6-12 and X*
  • Genes
  • Humans
  • Immunoglobulin Light Chains / genetics*
  • Leukemia, Lymphoid / genetics*
  • Nucleic Acid Hybridization
  • Philadelphia Chromosome*

Substances

  • Immunoglobulin Light Chains