The influence of Yaa on anti-DNA responses of B6-lpr mice

Clin Immunol Immunopathol. 1985 Dec;37(3):369-76. doi: 10.1016/0090-1229(85)90106-0.


The anti-DNA autoantibody responses of mice congenic for lpr and the Y-linked autoimmune accelerator (Yaa) genes were studied to evaluate genetic interactions in murine autoimmunity. Male B6-lpr, + mice failed to generate significant anti-DNA responses in comparison to B6-+, + mice. In contrast, B6-lpr mice bearing Yaa (B6-lpr, Yaa) had markedly increased IgG anti-DNA levels in comparison to both B6-+, + and B6-lpr, + mice. To determine whether anti-DNA levels reflected the overall B-cell response to lpr and Yaa, total IgG and IgM levels were also determined. This analysis demonstrated that the increase in IgG anti-DNA produced by mice with the Yaa gene was far greater than the increase in total IgG. Taken together, these results indicate that an impaired anti-DNA response related to one gene-determined mechanism for the development of autoimmunity does not preclude the response to another. Furthermore, it appears that the polyclonal B-cell activation during murine autoimmunity may be associated with the preferential expression of certain autoantibodies.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Animals
  • Antibodies, Antinuclear / analysis*
  • Antibody Formation
  • Female
  • Genes, MHC Class II
  • Genetic Linkage
  • Homozygote
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin M / biosynthesis
  • Life Expectancy
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Mutation
  • Y Chromosome


  • Antibodies, Antinuclear
  • Immunoglobulin G
  • Immunoglobulin M