Disparities in hepatitis C among people aged 12-59 with no history of injection drug use, United States, January 2013-March 2020

Liver Int. 2024 Dec;44(12):3250-3259. doi: 10.1111/liv.16108. Epub 2024 Sep 26.

Abstract

Background and aims: In the United States, hepatitis C virus (HCV) infection occurs primarily through injection drug use (IDU), but transmission also occurs through other ways. This study examined HCV prevalence and disparities among US residents aged 12-59 years with no IDU history.

Methods: We analysed 2013-March 2020 National Health and Nutrition Examination Survey data to calculate the HCV prevalence among people with no drug use history and only a non-IDU history, collectively referred to as no IDU history. These estimates were compared to those with an IDU history and stratified by sociodemographic and hepatitis A and hepatitis B serologic characteristics.

Results: The current HCV infection prevalence among people aged 12-59 was .7% overall, and specifically 17.2% among people with an IDU history, .9% among people with a non-IDU history and .2% among people with no drug use history. These rates represented 1.4 million people with current HCV infection, of whom, 730 000 had an IDU history, 262 000 had a non-IDU history and 309 000 had no drug use history. Among people with no drug use history, current HCV infection prevalence was higher for people born during 1954-1965 versus after 1965, had completed high school or less versus at least some college and had past/present hepatitis B versus vaccinated for hepatitis B.

Conclusion: While the HCV infection burden was highest among people with an IDU history, we found a sizeable burden among people without such a history. These findings support policies and practices aimed at addressing disparities among people needing treatment.

Keywords: HCV; disparities; hepatitis C; non‐traditional risk factors; prevalence.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Health Status Disparities
  • Hepatitis C* / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Nutrition Surveys*
  • Prevalence
  • Risk Factors
  • Substance Abuse, Intravenous* / epidemiology
  • United States / epidemiology
  • Young Adult