[Long-term therapy of familial hypercholesterolemia in young patients with colestipol: availability of minerals and vitamins]

Klin Wochenschr. 1985 Sep 2;63(17):802-6. doi: 10.1007/BF01732284.
[Article in German]

Abstract

Longterm treatment for 5 years of young patients with familial hypercholesterolemia was accompanied by monitoring of plasma levels of calcium, iron, sodium, parathyroid hormone and water- and fat soluble vitamins, since interference of the ion exchange resin with absorption of numerous substances as well as abnormal plasma levels of some of the above had been described in several studies. Treatment was effective in the group with good compliance (lowering of plasma cholesterol at the end of 5 years by 19% and, compared to the control group, by 23%). Adverse drug effects with respect to the above parameters were not found. Plasma levels of carotinoides and vitamin E were elevated in the patients according to elevated concentrations of lipoproteins which are carriers of these vitamins.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Blood Glucose / metabolism
  • Calcium / blood
  • Child
  • Child, Preschool
  • Chlorides / blood
  • Colestipol / adverse effects*
  • Colestipol / therapeutic use
  • Coronary Disease / prevention & control*
  • Female
  • Humans
  • Hyperlipoproteinemia Type II / drug therapy*
  • Iron / blood
  • Lipids / blood
  • Long-Term Care
  • Male
  • Minerals / blood*
  • Parathyroid Hormone / blood
  • Phosphates / blood
  • Polyamines / adverse effects*
  • Potassium / blood
  • Sodium / blood
  • Vitamins / blood*

Substances

  • Blood Glucose
  • Chlorides
  • Lipids
  • Minerals
  • Parathyroid Hormone
  • Phosphates
  • Polyamines
  • Vitamins
  • Sodium
  • Iron
  • Colestipol
  • Potassium
  • Calcium