12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion

Cancer Lett. 1985 Oct;29(1):79-84. doi: 10.1016/0304-3835(85)90126-0.

Abstract

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the non-promoter mezerein both induce ornithine decarboxylase activity in mouse epidermis by a route which can be blocked by indomethacin. In two-stage tumor promotion experiments in mice with mezerein as the stage II promoter, TPA was effective as the stage I promoter whether it was applied before or after an initiating dose of 7,12-dimethylbenz[a]anthracene (DMBA). There appear to be at least 4 events in promotion, only 3 of which are caused by second stage promoters.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 9,10-Dimethyl-1,2-benzanthracene
  • Animals
  • Carcinogens / toxicity
  • Cocarcinogenesis
  • Diterpenes*
  • Enzyme Induction / drug effects
  • Female
  • Mice
  • Models, Biological
  • Ornithine Decarboxylase / metabolism
  • Ornithine Decarboxylase Inhibitors
  • Papilloma / chemically induced*
  • Papilloma / enzymology
  • Phorbols / toxicity*
  • Skin Neoplasms / chemically induced*
  • Skin Neoplasms / enzymology
  • Terpenes / toxicity
  • Tetradecanoylphorbol Acetate / toxicity*
  • Time Factors

Substances

  • Carcinogens
  • Diterpenes
  • Ornithine Decarboxylase Inhibitors
  • Phorbols
  • Terpenes
  • mezerein
  • 9,10-Dimethyl-1,2-benzanthracene
  • Ornithine Decarboxylase
  • Tetradecanoylphorbol Acetate