Abstract
The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the non-promoter mezerein both induce ornithine decarboxylase activity in mouse epidermis by a route which can be blocked by indomethacin. In two-stage tumor promotion experiments in mice with mezerein as the stage II promoter, TPA was effective as the stage I promoter whether it was applied before or after an initiating dose of 7,12-dimethylbenz[a]anthracene (DMBA). There appear to be at least 4 events in promotion, only 3 of which are caused by second stage promoters.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene
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Animals
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Carcinogens / toxicity
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Cocarcinogenesis
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Diterpenes*
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Enzyme Induction / drug effects
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Female
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Mice
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Models, Biological
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Ornithine Decarboxylase / metabolism
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Ornithine Decarboxylase Inhibitors
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Papilloma / chemically induced*
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Papilloma / enzymology
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Phorbols / toxicity*
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Skin Neoplasms / chemically induced*
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Skin Neoplasms / enzymology
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Terpenes / toxicity
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Tetradecanoylphorbol Acetate / toxicity*
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Time Factors
Substances
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Carcinogens
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Diterpenes
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Ornithine Decarboxylase Inhibitors
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Phorbols
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Terpenes
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mezerein
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9,10-Dimethyl-1,2-benzanthracene
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Ornithine Decarboxylase
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Tetradecanoylphorbol Acetate