Bacterial Pigments as a Promising Alternative to Synthetic Colorants: From Fundamentals to Applications

J Microbiol Biotechnol. 2024 Nov 28;34(11):2153-2165. doi: 10.4014/jmb.2404.04018. Epub 2024 Sep 11.

Abstract

Pigments find widespread application in the fields of food, medicine, textiles, and cosmetics. At present, synthetic colorants dominate the global pigment market. However, the environmental and health hazards associated with synthetic colorants have spurred extensive research on eco-friendly and safe alternatives. Natural pigments are particularly intriguing for meeting consumer demands and sustainable development, as they not only exhibit various vibrant color shades without discernible toxic side effects but also offer additional healthful features such as antibacterial, antioxidant, anticancer, and antiviral properties compared with their synthetic counterparts. Among natural sources, bacterial strains share distinct advantages for large-scale pigment production because of their intrinsic robustness of cellular metabolic systems. This review comprehensively outlines the bacterial sources, extraction and purification methods, structural characteristics, biological activities, and potential applications of typical pigments, including but not limited to violacein, indigoidine, melanin, carotenoids, prodigiosin, and rhodopsin. Additionally, it underscores the primary obstacles to the development and production of bacterial pigments for commercial applications, discussing feasible strategies for overcoming production bottlenecks. This work also provides valuable insights for the scientific and rational advancement of bacterial pigment development.

Keywords: Bacterial pigments; biological activity; biosynthesis; chemical structure; pigment classification.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Bacteria* / drug effects
  • Carotenoids / chemistry
  • Coloring Agents / chemistry
  • Indoles / chemistry
  • Indoles / metabolism
  • Melanins / biosynthesis
  • Melanins / chemistry
  • Melanins / metabolism
  • Pigments, Biological* / chemistry
  • Pigments, Biological* / isolation & purification
  • Prodigiosin / analogs & derivatives
  • Prodigiosin / chemistry
  • Prodigiosin / pharmacology

Substances

  • Pigments, Biological
  • Coloring Agents
  • Carotenoids
  • Anti-Bacterial Agents
  • Antioxidants
  • Prodigiosin
  • Melanins
  • Indoles
  • violacein