A promising alternative to opioids

Elife. 2024 Sep 30:13:e103003. doi: 10.7554/eLife.103003.

Authors

Jie Zhang^{1

2}, Jianguo Cheng^{1

2}

Affiliations

¹ Department of Pain Management, Cleveland Clinic, Cleveland, United States.
² Department of Neuroscience, Cleveland Clinic, Cleveland, United States.

Abstract

A complex extracted from the amniotic membrane in humans reduces post-surgical pain in mice by directly inhibiting pain-sensing neurons.

Keywords: HC-HA/PTX3; Post-surgical pain; amniotic membrane; clarix FLO; medicine; mouse; neuroscience; opioids.

© 2024, Zhang and Cheng.

Publication types

Editorial

MeSH terms

Amnion
Analgesics, Opioid* / pharmacology
Animals
Humans
Mice
Neurons / drug effects
Neurons / physiology
Pain, Postoperative* / drug therapy

Substances

Analgesics, Opioid