Measurement of retinal blood flow precision in the human eye with multimodal adaptive optics imaging

Biomed Opt Express. 2024 Jul 11;15(8):4625-4641. doi: 10.1364/BOE.524944. eCollection 2024 Aug 1.

Abstract

Impaired retinal blood flow (RBF) autoregulation plays a key role in the development and progression of several ocular diseases, including glaucoma and diabetic retinopathy. Clinically, reproducible RBF quantitation could significantly improve early diagnosis and disease management. Several non-invasive techniques have been developed but are limited for retinal microvasculature flow measurements due to their low signal-to-noise ratio and poor lateral resolution. In this study, we demonstrate reproducible vessel caliber and retinal blood flow velocity measurements in healthy human volunteers using a high-resolution (spatial and temporal) multimodal adaptive optics system with scanning laser ophthalmoscopy and optical coherence tomography.

Associated data

  • figshare/10.6084/m9.figshare.26152927