Lymphoid nodules and nodular lymphoid hyperplasia in bone marrow biopsies

Acta Haematol. 1985;74(1):19-22. doi: 10.1159/000206157.

Abstract

Out of 2,474 bone marrow biopsies we have observed 330 cases (13.3%) with presence of lymphoid nodules (LN). LN were frequent in old age (24.6% over 80 years), in females (17%) and in some diseases, such as rheumatoid arthritis and systemic lupus erythematosus (73.7% of the cases), partial aplasia (34%), hypersplenism (30.4%), hemopoietic dysplasia (25%), chronic renal failure (20.4%), polycythemia vera (20.2%), idiopathic thrombocytopenic purpura (18.8%), acute leukemia (17.7%). Nodular lymphoid hyperplasia of the bone marrow was found especially in systemic autoimmune diseases (26.3%), hypersplenism (9.8%), preleukemia (7.3%) and acute leukemia (4.2%). The presence of excessive medullary LN could indicate a bone marrow microenvironment damage, possibly of autoimmune origin.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Biopsy
  • Bone Marrow / pathology*
  • Child
  • Child, Preschool
  • Female
  • Hematologic Diseases / pathology
  • Humans
  • Hyperplasia / epidemiology
  • Hyperplasia / pathology
  • Immune System Diseases / pathology
  • Infant
  • Infant, Newborn
  • Lymphoid Tissue / pathology*
  • Male
  • Middle Aged