Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes

Cell. 1985 Dec;43(2 Pt 1):507-19. doi: 10.1016/0092-8674(85)90180-1.


The bithorax complex of Drosophila is composed of three major units of gene function, Ultrabithorax (Ubx), abdominal-A (abd-A), and Abdominal-B (Abd-B), each having a precise realm of action within the thorax and abdomen. Recent molecular studies have established that the transcripts and protein products of the Ubx gene are expressed principally in a restricted portion of the body, beginning in the second thoracic segment and ending in the eighth abdominal segment (i.e., in parasegments 5-13). However, within this region, both show complex, heterogeneous patterns of expression. Using mutations in the abd-A, Abd-B, and esc (extra sex combs) genes we show that these distinct patterns result in large part from regulation of Ubx gene expression by the abd-A and Abd-B gene functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Drosophila melanogaster / anatomy & histology
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development
  • Embryo, Nonmammalian / anatomy & histology
  • Gene Expression Regulation*
  • Larva / anatomy & histology
  • Morphogenesis
  • Transcription, Genetic