4-Dimethylaminophenol and dicobalt edetate (Kelocyanor) in the treatment of experimental cyanide poisoning

Hum Toxicol. 1985 Nov;4(6):591-600. doi: 10.1177/096032718500400605.

Abstract

The efficacy of dicobalt edetate (Kelocyanor) was compared against that of 4-dimethylaminophenol (DMAP) in experimental cyanide poisoning. DMAP gave better survival. The efficacy has been related to the toxicity of the two compounds.

MeSH terms

  • Aminophenols / pharmacology*
  • Animals
  • Antidotes*
  • Cyanides / blood
  • Cyanides / poisoning*
  • Dogs
  • Edetic Acid / pharmacology*
  • Female
  • Methemoglobinemia / chemically induced
  • Time Factors

Substances

  • Aminophenols
  • Antidotes
  • Cyanides
  • cobalt-ethylenediamine tetraacetic acid chelate
  • Edetic Acid
  • 4-dimethylaminophenol