Splenic nociceptive neural connection promotes humoral immunity

Cheng Qian; Jiaming Wang; Xuetao Cao

doi:10.1016/j.tins.2024.09.008

Splenic nociceptive neural connection promotes humoral immunity

Trends Neurosci. 2024 Dec;47(12):968-970. doi: 10.1016/j.tins.2024.09.008. Epub 2024 Oct 2.

Authors

Cheng Qian¹, Jiaming Wang², Xuetao Cao³

Affiliations

¹ National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, China. Electronic address: qianc@immunol.org.
² Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
³ National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Naval Medical University, Shanghai, China; Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China; Institute of Immunology, College of Life Sciences, Nankai University, Tianjin, China. Electronic address: caoxt@immunol.org.

PMID: 39358065
DOI: 10.1016/j.tins.2024.09.008

Abstract

Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.

Keywords: CGPR; immune regulation; inflammation; neuroimmune crosstalk; peripheral sensory neurons; tissue microenvironments.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ganglia, Spinal / immunology
Ganglia, Spinal / metabolism
Humans
Immunity, Humoral* / immunology
Immunity, Humoral* / physiology
Mice
Nociceptors* / immunology
Nociceptors* / physiology
Spleen* / immunology
Spleen* / innervation