The effect of 6-hydroxydopamine and some hypotensive drugs on lypressin induced hypertension in rats

Abstract

Intracerebroventricular injection of 6-hydroxydopamine (6-OH-DA) prevented the development of the lypressin (LVP)-induced hypertension. Administration of 6-OH-DA to hypertensive rats significantly decreased, but did not normalize, blood pressure. A fourteen-day treatment with clonidine, guanethidine, reserpine, dihydralazine, propranolol and furosemide produced a transient decrease in blood pressure in LVP-hypertensive rats. Eight weeks after the withdrawal of hypotensive drugs blood pressure again reached the value corresponding to that in untreated LVP-hypertensive rats.