Single-dose cefuroxime axetil in the treatment of uncomplicated gonorrhea: a controlled trial

Sex Transm Dis. Oct-Dec 1985;12(4):184-7. doi: 10.1097/00007435-198510000-00003.

Abstract

One hundred eighty-four patients were enrolled in a randomized study that evaluated the efficacy and toxicity of a single dose of orally administered cefuroxine axetil in the treatment of men and women with uncomplicated gonorrhea. Sixty-two patients received cefuroxine axetil alone, 62 received cefuroxine axetil and probenecid, and 60 received amoxicillin plus probenecid. Cure rates in the three groups were 98%, 98%, 96%, respectively. Only 2% of patients who received cefuroxine axetil alone complained of nausea, as compared with 11% of those who received a regimen that contained probenecid (P less than .05). The results show that cefuroxime axetil is effective and nontoxic in the treatment of uncomplicated gonococcal infections in adults.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amoxicillin / administration & dosage
  • Amoxicillin / therapeutic use
  • Cefuroxime / administration & dosage
  • Cefuroxime / analogs & derivatives*
  • Cefuroxime / therapeutic use
  • Cephalosporins*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Female
  • Gonorrhea / drug therapy*
  • Humans
  • Male
  • Neisseria gonorrhoeae / drug effects
  • Probenecid / administration & dosage
  • Probenecid / therapeutic use
  • Random Allocation

Substances

  • Cephalosporins
  • Amoxicillin
  • Cefuroxime
  • Probenecid
  • cefuroxime axetil