Effects of inspiratory muscle training on pulmonary function, diaphragmatic thickness, balance and exercise capacity in people after stroke: a systematic review and meta-analysis

Disabil Rehabil. 2025 Jun;47(12):2981-2996. doi: 10.1080/09638288.2024.2408606. Epub 2024 Oct 3.

Abstract

Purpose: To examine the effects of inspiratory muscle training (IMT) on pulmonary and diaphragmatic function, exercise capacity, balance and quality of life (QOL), in post-stroke individuals.

Methods: A literature search was conducted using MEDLINE, CINAHL, EMBASE, PubMed, PEDro, Web of Science and China Biological Medicine databases. Randomized controlled trials (RCTs) with a PEDro score ≥6 focusing on the effects of IMT were included. The GRADE system was used to determine the certainty of evidence for each outcome.

Results: Nine studies (255 participants) were included. IMT significantly increased forced expiratory volume in one second (FEV1) (4 studies, 112 participants, mean difference (MD)=0.18 litre, 95% confidence interval (CI): 0.14-0.23); maximal inspiratory pressure (MIP) (8 studies, 226 participants, MD = 6.37 cm H2O, 95% CI: 1.26-11.49); and diaphragm thickness fraction (DTf) on both sides (MD of affected side vs. unaffected side: 51 vs. 37%). The evidence certainty for diaphragmatic function was moderate. No significant change was observed in forced vital capacity (FVC), balance function, exercise capacity and QOL.

Conclusion: This review reveals moderate evidence certainty in support of IMT improving diaphragmatic function. It appears that a training intensity between 30 and 50% MIP results in a significantly improved MIP.

Keywords: Stroke; diaphragmatic thickness; inspiratory muscle training; pulmonary function; systematic review.

Plain language summary

Stroke not only impacts motor function but also affects respiratory function, especially diaphragmatic function.Inspiratory muscle training (IMT) is an intervention that has been used to improve the strength and endurance of inspiratory muscles.There is evidence of moderate certainty which cautiously recommends IMT to improve diaphragmatic function after stroke.The evidence supporting IMT for the enhancement of forced vital capacity, balance function, exercise capacity and quality of life in stroke patients is inadequate.

Publication types

  • Systematic Review
  • Meta-Analysis

MeSH terms

  • Breathing Exercises* / methods
  • Diaphragm* / physiopathology
  • Exercise Tolerance* / physiology
  • Humans
  • Postural Balance* / physiology
  • Quality of Life
  • Randomized Controlled Trials as Topic
  • Respiratory Function Tests
  • Respiratory Muscles* / physiopathology
  • Stroke / physiopathology
  • Stroke Rehabilitation* / methods