The Art of Ultrafiltration, from Pump to Peritoneum

Cardiorenal Med. 2024;14(1):588-599. doi: 10.1159/000541931. Epub 2024 Oct 9.

Abstract

Background: Heart failure remains a significant public health burden given its prevalence, morbidity, mortality as well its untoward financial consequences.

Summary: The assessment of congestion and its treatment are integral in heart failure pathophysiology and outcomes. Renal venous congestion and its suboptimal response to diuretic-based and novel pharmacological therapeutic regimens have thus positioned ultrafiltration as a promising therapeutic option for patients with acute decompensated heart failure. As a corollary, peritoneal dialysis has had success establishing itself as a relevant therapeutic option for chronic cardiorenal syndrome in patients with heart failure.

Key messages: Herein, we will discuss the pathophysiologic basis of ultrafiltration and peritoneal dialysis in heart failure with a review of the relevant clinical trials on safety and efficacy profiles in these patient populations.

Keywords: Cardiorenal syndrome; Heart failure; Peritoneal dialysis; Ultrafiltration.

Publication types

  • Review

MeSH terms

  • Cardio-Renal Syndrome / physiopathology
  • Cardio-Renal Syndrome / therapy
  • Heart Failure* / physiopathology
  • Heart Failure* / therapy
  • Humans
  • Peritoneal Dialysis* / methods
  • Ultrafiltration* / methods