Alterations in optical coherence tomography angiography parameters after cataract surgery in patients with diabetes

Sci Rep. 2024 Oct 11;14(1):23814. doi: 10.1038/s41598-024-73830-w.

Abstract

This prospective study aimed to investigate microvascular changes in diabetic patients undergoing cataract surgery. Foveal avascular zone (FAZ) area, as well as vessel density (VD) in the macula and radial peripapillary capillary plexus (RPC), were compared before and after surgery. Sixty eyes (72.3%) had no diabetic retinopathy (no DR group) and 23 eyes (27.7%) had non-proliferative diabetic retinopathy (DR group). In the no DR group, the FAZ area in the superficial capillary plexus (SCP) decreased from 0.41 ± 0.13 to 0.38 ± 0.11 mm2 (P = 0.036), while no significant change was observed in the DR group (0.33 ± 0.12 to 0.30 ± 0.12 mm2, P = 0.091) at 6 months postoperatively. VD in the RPC increased from 34.4 ± 2.3% to 35.6 ± 2.3% in the no DR group (P = 0.009), but there was no significant change in the DR group (33.0 ± 3.5% vs. 34.0 ± 2.3%, P = 0.051) after 6 months. VD in the macula did not change in either group. Phacoemulsification reduced the FAZ area in the SCP and increased the VD in the RPC in diabetic patients without diabetic retinopathy at six months postoperatively.

MeSH terms

  • Aged
  • Cataract / complications
  • Cataract / diagnostic imaging
  • Cataract Extraction*
  • Diabetic Retinopathy* / diagnostic imaging
  • Diabetic Retinopathy* / surgery
  • Female
  • Fluorescein Angiography / methods
  • Fovea Centralis / blood supply
  • Fovea Centralis / diagnostic imaging
  • Fovea Centralis / pathology
  • Humans
  • Macula Lutea / diagnostic imaging
  • Macula Lutea / pathology
  • Macula Lutea / surgery
  • Male
  • Middle Aged
  • Prospective Studies
  • Retinal Vessels / diagnostic imaging
  • Retinal Vessels / pathology
  • Tomography, Optical Coherence* / methods