B cell heterogeneity in cancer comes of age

Colleen Sturdevant; Yuliya Pylayeva-Gupta

doi:10.1016/j.ccell.2024.09.013

B cell heterogeneity in cancer comes of age

Cancer Cell. 2024 Oct 14;42(10):1650-1652. doi: 10.1016/j.ccell.2024.09.013.

Authors

Colleen Sturdevant¹, Yuliya Pylayeva-Gupta²

Affiliations

¹ Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
² Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Department of Genetics, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Electronic address: yuliyap1@email.unc.edu.

Abstract

The role of B cells in cancer remains incompletely understood. Three recent publications, including a study by Fitzsimons et al. in this issue of Cancer Cell,¹ use single-cell RNA sequencing to define pan-cancer atlases of tumor-infiltrating B cell subsets, paving the way for profound advances in our understanding of B cell-dependent antitumor immunity.

MeSH terms

Animals
B-Lymphocyte Subsets / immunology
B-Lymphocytes / immunology
Genetic Heterogeneity
Humans
Lymphocytes, Tumor-Infiltrating / immunology
Neoplasms* / genetics
Neoplasms* / immunology
Neoplasms* / pathology
Single-Cell Analysis / methods

Abstract

MeSH terms

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