A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes

Nature. 1986 Jan 23-29;319(6051):291-5. doi: 10.1038/319291a0.


Three independent pseudoautosomal loci are linked to sex determination at frequencies which define a gradient of linkage. The segregation patterns of these loci indicate that X/Y recombination results from a single obligatory meiotic crossing-over in the pseudoautosomal region. Recombination in male germ cells in the terminal regions of the short arms of the X and Y chromosomes in 10-fold greater than between the same regions of the X chromosomes in female germ cells.

MeSH terms

  • Animals
  • Crossing Over, Genetic*
  • DNA / genetics
  • Female
  • Genetic Linkage
  • Humans
  • Male
  • Meiosis
  • Mice
  • Phenotype
  • Recombination, Genetic
  • X Chromosome / physiology*
  • Y Chromosome / physiology*


  • DNA