Effect of cannabidiol (CBD), a cannabis plant derivative, against Candida albicans growth and biofilm formation

Maryam Bahraminia; Shujun Cui; Ze Zhang; Abdelhabib Semlali; Étienne Le Roux; Kelly-Anne Giroux; Camille Lajoie; François Béland; Mahmoud Rouabhia

doi:10.1139/cjm-2024-0034

Effect of cannabidiol (CBD), a cannabis plant derivative, against Candida albicans growth and biofilm formation

Can J Microbiol. 2025 Jan 1:71:1-13. doi: 10.1139/cjm-2024-0034. Epub 2024 Oct 17.

Authors

Maryam Bahraminia^{1

2

3}, Shujun Cui^{1

2

3}, Ze Zhang^{2

3}, Abdelhabib Semlali¹, Étienne Le Roux⁴, Kelly-Anne Giroux⁴, Camille Lajoie⁴, François Béland⁴, Mahmoud Rouabhia¹

Affiliations

¹ Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire Université Laval, Quebec City, QC, Canada.
² Axe Médecine Régénératrice Centre de Recherche du CHU de Québec - Université Laval, Quebec City, QC, Canada.
³ Département de Chirurgie Faculté de Médecine, Université Laval, Quebec City, QC, Canada.
⁴ SiliCycle Inc., 2500 Bd du Parc Technologique, Quebec City, QC G1P 4S6, Canada.

PMID: 39418672
DOI: 10.1139/cjm-2024-0034

Abstract

Cannabidiol (CBD) decreases the growth of C. albicans. CBD inhibits the yeast-to-hyphae transition. CBD reduces biofilm formation by C. albicans. CBD induces C. albicans death through necrosis.

Keywords: CBD; Candida albicans; biofilm; cannabis; growth; necrosis.

MeSH terms

Antifungal Agents* / pharmacology
Biofilms* / drug effects
Biofilms* / growth & development
Candida albicans* / drug effects
Candida albicans* / growth & development
Candida albicans* / physiology
Cannabidiol* / pharmacology
Cannabis* / chemistry
Hyphae / drug effects
Hyphae / growth & development

Substances

Cannabidiol
Antifungal Agents